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Cancer Cell death Cell cycle Cytoskeleton Exo/endocytosis Differentiation Division Organelles Signalling Stem cells Trafficking
Cell Biology International (1994) 18, 111–118 (Printed in Great Britain)
Increased secretion of latent elastase activity following contact between human skin fibroblasts and elastin derived peptides.
Jean‑Marie Landeau, Bernard Pellat and William Hornebeck
Biochemistry department, Faculty of Dental Surgery, University René Descartes PARIS V, 1 rue Maurice Arnoux, 92120 Montrouge, FRANCE and Laboratoire de Biologie du tissu conjonctif, University PARIS XII, Faculty of Medicine; E.R. C.N.R.S. 74; 8 rue du Général Sarrail, 94010 Créteil, FRANCE.


Elastin-derived peptides were previously shown to influence human skin fibroblasts (HSF) chemotaxis and proliferation (Ghuysen et al., 1992). We report here that culturing HSF on κ-elastin (κE) but not onto fibronectin (FN) enhanced the secretion of latent elastinolytic activity. The proteinase involved was identified as the 72 kDa gelatinase A. Moreover, HSF-κE as well as HSF-FN interactions modulated the secretions of Il1 induced expressions of elastinolytic activities.

Key words: fibroblasts, elastase activity, gelatinase(s), elastin-derived peptides.


ISSN Print: 1065-6995
ISSN Electronic: 1095-8355
Published by Portland Press Limited on behalf of the International Federation for Cell Biology (IFCB)