|Cancer||Cell death||Cell cycle||Cytoskeleton||Exo/endocytosis||Differentiation||Division||Organelles||Signalling||Stem cells||Trafficking|
Cell Biology International (1997) 21, 787792 (Printed in Great Britain)
HISTONES AS EXTRACELLULAR MESSENGERS: EFFECTS ON GROWTH HORMONE SECRETION
O.A. BROWN, Y.E. SOSA and R.G. GOYA
aINIBIOLP—Histology and Embryology ‘B’, Faculty of Medicine, National University of La Plata, CC455, 1900, La Plata, Argentina
Histones display hormone-like properties when present in extracellular fluids. The authors report that histones H2A and H2B possess growth hormone (GH)-releasing activityin vitroand describe the specificity and signal transduction pathways involved in these effects. Perfused and incubated rat pituitary cells were used in different sets of experiments and GH release was measured by radio-immunoassay (RIA). Perfusion of cells with 30
Key words: histones, pituitary cells, GH, MB35, calcium, diacylglycerol.