|Cancer||Cell death||Cell cycle||Cytoskeleton||Exo/endocytosis||Differentiation||Division||Organelles||Signalling||Stem cells||Trafficking|
Cell Biology International (2000) 24, 621633 (Printed in Great Britain)
POLYPLOID GIANT CELLS PROVIDE A SURVIVAL MECHANISM FOR p53 MUTANT CELLS AFTER DNA DAMAGE
Timothy M. Illidgeab,f1, Mark S. Craggb, Birgitta Fringesc, Peggy Olived and Jekaterina A. Erenpreisae
aCRC Department of Oncology, Southampton General Hospital, Southampton University, Southampton, SO16 6YD, U.K.
bTenovus Cancer Research Laboratory, Southampton General Hospital, Southampton University, Southampton, SO16 6YD, U.K.
cDepartment of Pathology, University of Giessen, Germany
dTerry Fox Cancer Centre, British Columbia, Vancouver, Canada, V5Z 1L3
eLaboratory Tumor Cell Biology, Latvian University Biomedicine Centre, Riga, LV-1067, Latvia
The relationships between delayed apoptosis, polyploid ‘giant’ cells and reproductive survivors were studied in p53-mutated lymphoma cells after DNA damage. Following severe genotoxic insult with irradiation or chemotherapy, cells arrest at the G
Key words: apoptosis, endoreduplication, p53 mutation, giant cells, polyploidy, tumour.
f1To whom correspondence should be addressed, at CRC Department of Oncology, Southampton General Hospital, Southampton University, SO16 6YD, U.K. E-mail:firstname.lastname@example.org
Received 11 January 2000; accepted 3 May 2000doi:10.1006/cbir.2000.0557