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Cell Biology International (2001) 25, 11171124 (Printed in Great Britain)
SAW PALMETTO BERRY EXTRACT INHIBITS CELL GROWTH AND COX-2 EXPRESSION IN PROSTATIC CANCER CELLS
Wolfgang H. Goldmanna,f2, Amita L. Sharmaa, Steve J. Currierb, Paul D. Johnstonb, Ajay Ranac and C. Pal Sharmaa,f1
aBoston BioProducts Inc. Ashland, MA, 01721, U.S.A.
bPharmaPrint Inc. Irvine, CA, 92612, U.S.A.
cMassachusetts General Hospital, Boston, MA, 02114, U.S.A.
The cytotoxicity of a commonly used material to alleviate the symptoms of benign prostatic hyperplasia (BPH), Saw Palmetto Berry Extract (SPBE), was examined as neat oil using a set of prostatic cell lines; 267B-1, BRFF-41T and LNCaP. Proliferation of these prostatic derived cell lines is inhibited to different degrees when dosed for 3 days with SPBE. The amount of SPBE required to inhibit 50% growth (IC
Keywords: Saw Palmetto berry extract, cell growth inhibition, MTT and SRB assays, Cox-2, Cox-1, Bcl-2.
f2Dr Goldmann’s current address: Renal Unit, Massachussetts General Hospital, Room 8200, Building 149, 13th Street, Charlestown, MA 02129, U.S.A.
f1To whom all correspondence should be addressed. C. Pal Sharma, Boston Bioproducts Inc., 200 Homer Ave, Ashland, MA 01721, U.S.A. Tel: +1 508 881 7755; Fax: +1 508 881 7368; E-mail:Cpalsharma@msn.com.
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Received 14 August 2000; accepted 2 April 2001doi:10.1006/cbir.2001.0779