|Cancer||Cell death||Cell cycle||Cytoskeleton||Exo/endocytosis||Differentiation||Division||Organelles||Signalling||Stem cells||Trafficking|
Cell Biology International (2001) 25, 777784 (Printed in Great Britain)
LINOLEIC AND LINOLELAIDIC ACIDS DIFFERENTIALLY INFLUENCE PROLIFERATION AND APOPTOSIS OF MOLT-4 LEUKAEMIA CELLS
M.C. Phoona, Charles Desbordesb, J. Howea and Vincent T.K. Chowaf1
aDepartment of Microbiology, Faculty of Medicine, National University of Singapore, Kent Ridge, Singapore, 117597, Republic of Singapore
bDepartment of Biology, Medgar Evers College, City University of New York, New York, NY, 11225, U.S.A.
The effects of varying concentrations of linoleic acid and its transisomer linolelaidic acid on the proliferation the ultrastructural morphology of MOLT-4 T-lymphoblastic leukaemia cells were investigated. At 2 and 4 days after exposure to the fatty acids, the cells were counted by flow cytometry and observed by electron microscopy. After 4 days of treatment, linoleic acid was growth stimulatory at concentrations of 200
Key words: linoleic acid, linolelaidic acid, MOLT-4, cell proliferation, apoptosis, p53 alternative splicing.
f1To whom correspondence should be addressed. Fax: 65 776 6872. E-mail:email@example.com
Received 19 October 2000; accepted 31 January 2001doi:10.1006/cbir.2001.0733