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Cell Biology International (2001) 25, 931–934 (Printed in Great Britain)

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SUBSTRATE-INDUCED POLARISATION OF CULTURED EPITHELIOCYTES AND FIBROBLASTS: NON-REACTIVITY OF RAS-TRANSFORMED CELLS

Tatjana G. Moizhess and Jury M. Vasiliev^f1

Cancer Research Centre of Russian Academy of Medical Sciences, Kashirskoe Shosse, 24, 115478, Moscow, Russia

Abstract

Non-transformed epitheliocytes and fibroblasts undergo modulations between the less polarised and more polarised phenotypes depending on the nature of the substrate. In contrast, transformed cells express polarised phenotype regardless of the substrate.

Key words: cell shape, cell polarisation, substrates, morphometry.

^f1To whom correspondence should be addressed. Fax: 7(095)-324-12-05; E-mail:vasiliev@cityline.ru

Received 6 February 2001; accepted 15 February 2001