Brought to you by Portland Press Ltd.
Published on behalf of the International Federation for Cell Biology
Cancer Cell death Cell cycle Cytoskeleton Exo/endocytosis Differentiation Division Organelles Signalling Stem cells Trafficking
Cell Biology International (2001) 25, 1081–1090 (Printed in Great Britain)
CONSERVED CELLULAR AND MOLECULAR MECHANISMS IN DEVELOPMENT
Giovanni Giudicef1
Dipartimento di Biologia Cellulare e dello Sviluppo, Viale delle Scienze, 90128, Palermo, Italy


Abstract

This review discusses examples of conserved cellular and molecular mechansims in development, including the pathway of signal transduction between the photoreceptors R8 and R7 in Drosophila, which is compared to vulval induction in Caenorhabditis elegans. The Wg pathway in Drosophila is compared, first, to theWnt pathway in dorsal mesoderm specification in Xenopus; second, to the same pathway in sea urchins; third, to the equivalent in the mom cascade of C. elegans; and finally, to parts of the equivalent pathway inDictyostelium discoideum . The conserved expression of some hox genes in vertebrate limb buds and in the heads or tails of several invertebrate and vertebrate embryos is also illustrated. Two further examples show the contrast between BMP4 and the proteins Noggin, Chordin, Follistatin and Gremlin. Another example concerns the binding of proteins to the 3′UTRs of several messages which inhibits their translation in Drosophila and C. elegans. The final example illustrates the selective transfer of transcription factors to nuclei in Drosophila and C. elegans.


Key words: development, gene expression regulation, cell interactions.

f1Correspondence to: Giovanni Giudice. Fax: 0039 091 6577 430. Email:giudice@unipa.it


Received 14 September 2000; accepted 7 June 2001

doi:10.1006/cbir.2001.0793


ISSN Print: 1065-6995
ISSN Electronic: 1095-8355
Published by Portland Press Limited on behalf of the International Federation for Cell Biology (IFCB)