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Cell Biology International (2004) 28, 119124 (Printed in Great Britain)
A perspective on inversin
Lorraine Eleya, Lee Turnpennyb, Laura M Yatesa, A.Scott Craigheada, David Morgana, Catherine Whistlera, Judith A Goodshipa* and Tom Strachana,*
aInstitute of Human Genetics, University of Newcastle, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
bDivision of Human Genetics, University of Southampton, Duthie Building, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Over the past 5 years, there has been increasing evidence for the role of primary (9+0) cilia in renal physiology and in establishing the left–right axis. The cilia in the renal tract are immotile and thought to have a sensory function. Cilia at the murine embryonic node have a vortical movement that sets up a leftward flow. Inversin, the protein defective in the inv mouse and in patients with type-2 nephronophthisis, localizes to both renal and node primary cilia. However, we present evidence that it is also expressed before the node forms and that its subcellular localization in renal tubular cells is not confined to the cilia. Its role in both the pathway determining left–right axis and renal function remains to be elucidated.
Key words: Inversin, Situs inversus, Primary cilia, Nephronopthisis.
*Corresponding authors. Tel.: +44-191-241-8616; fax: +44-191-2418699
Received 2 October 2003; accepted 4 November 2003doi:10.1016/j.cellbi.2003.11.009