|Cancer||Cell death||Cell cycle||Cytoskeleton||Exo/endocytosis||Differentiation||Division||Organelles||Signalling||Stem cells||Trafficking|
Cell Biology International (2004) 28, 905911 (Printed in Great Britain)
Metallothionein protects bone marrow stromal cells against hydrogen peroxide-induced inhibition of osteoblastic differentiation
An‑Ling Liua*, Zhong‑Ming Zhangb, Bi‑Feng Zhua, Zhao‑Hui Liaoa and Zhu Liua
aYingdong College of Biotechnology, Shaoguan University, Shaoguan, Guangdong Province 512005, PR China
bDepartment of Orthopaedics and Spinal Surgery, NanFang Hospital, The First Military Medical University, Guangzhou 510515, PR China
Metallothionein (MT), a cysteine-rich, metal-binding protein, is involved in homeostatic regulation of essential metals and protection of cells against oxidative injury. It has been shown that oxidative stress is associated with pathogenesis of osteoporosis and is capable of inhibiting osteoblastic differentiation of bone cells by nuclear factor-κB (NF-κB). In this study, the effect of MT on oxidative stress-induced inhibition of osteoblast differentiation was examined. 50–200
Key words: Metallothionein, Oxidative stress, Osteoblast, Differentiation, Hydrogen peroxide, Osteoporosis.
*Corresponding author. Tel.: +86 20 61360535; fax: +86 751 8120069.
Received 6 April 2004/2 September 2004; accepted 13 September 2004doi:10.1016/j.cellbi.2004.09.004