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Cell Biology International (2006) 30, 101113 (Printed in Great Britain)
Modulation of the epithelial barrier by dexamethasone and prolactin in cultured Madin–Darby canine kidney (MDCK) cells
E.B.M.I. Peixoto and C.B. Collares‑Buzato*
Department of Histology and Embryology, Institute of Biology, State University of Campinas (UNICAMP), Campinas, CP 6109, R. Charles Darwin s/n, 13083-970 Campinas, SP, Brazil
Glucocorticoids and prolactin (PRL) have a direct effect on the formation and maintenance of tight junctions (TJs) in cultured endothelial and mammary gland epithelial cells. In this work, we investigated the effect of a synthetic glucocorticoid dexamethasone (DEX) and PRL on the paracellular barrier function in MDCK renal epithelial cells. DEX (4
Key words: Epithelial barrier, Tight junction, Dexamethasone, Prolactin, MDCK cell line, Kidney, Junctional proteins.
*Corresponding author. Tel.: +55 19 3788 6246; fax: +55 19 3289 3124.
Received 18 August 2005; accepted 22 August 2005doi:10.1016/j.cellbi.2005.08.004