|Cancer||Cell death||Cell cycle||Cytoskeleton||Exo/endocytosis||Differentiation||Division||Organelles||Signalling||Stem cells||Trafficking|
Cell Biology International (2006) 30, 114121 (Printed in Great Britain)
Involvement of caspase-3 pathway in anti-apoptotic action of methionine enkephalin on CEM
Jin Xua, Shuqin Xinb, Hui Lia, Lin Liub, Weiyi Xiaa, Pingfeng Lia, Xinhua Liua and Gang Lia*
aDepartment of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100083, China
bMedicine and Health Analytical Center, Peking University Health Science Center, Beijing 100083, China
The roles of methionine enkephalin, as an immunomodulator, on immunodeficiency virus-induced apoptosis of lymphocytes during prolonged infection are still unclear. In the present study, we evaluated the effects of methionine enkephalin on the viability, the profile of cell cycle and apoptosis, as well as the expression of apoptosis-related genes in CEM
Key words: Methionine enkephalin, Simian immunodeficiency virus, Lymphocytes, Apoptosis, Opiate, Receptor, AIDS.
*Corresponding author. Department of Biochemistry and Molecular Biology, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100083, China. Tel./fax: +86 10 82802891.
Received 19 July 2005/1 August 2005; accepted 22 August 2005doi:10.1016/j.cellbi.2005.08.011