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Cell Biology International (2006) 30, 439–444 (Printed in Great Britain)
Design of compliance chamber and after-load in apparatus for cultured endothelial cells subjected to stresses
Hao Dingab, Aike Qiaoa, Lixing Shenb, Mingyang Lib, Zhenglong Chenb, Xiaojun Yuc and Yanjun Zengac*
aBiomechanics & Medical Information Institute, Beijing University of Technology, No. 100 PingLeYuan, Beijing 100022, China
bThe Medical Instrumentation College, University of Shanghai for Science and Technology, Shanghai 200093, China
cMedical College of Shantou University, Shantou 515031, China


Abstract

In order to create a hemodynamic environment that can simulate the physiological condition of arteries, an in vitro experiment apparatus was designed whose key modules were compliance chamber and after-load. These two modules were developed based on the theories of hemodynamics. Both the normal and shear stress to which endothelial cells are exposed can be controlled with these modules, thus facilitating the research of endothelial cells subjected to stresses.


Key words: Biomechanics, Hemodynamic environment, Experiment, Simulation, Blood flow, Artery.

*Corresponding author. Biomechanics & Medical Information Institute, Beijing University of Technology, No. 100 PingLeYuan, Beijing 100022, China. Tel.: +86 10 67391685.


Received 28 November 2005/10 January 2006; accepted 14 February 2006

doi:10.1016/j.cellbi.2006.02.003


ISSN Print: 1065-6995
ISSN Electronic: 1095-8355
Published by Portland Press Limited on behalf of the International Federation for Cell Biology (IFCB)