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Cell Biology International (2006) 30, 727732 (Printed in Great Britain)
CD38 expression enhances sensitivity of lymphoma T and B cell lines to biochemical and receptor-mediated apoptosis
Armando Gregorinia*, Marco Tomasettib, Cristina Cintib, Daniela Colombac and Stella Colombad
aIstituto di Psicologia “L. Meschieri”, Università di Urbino “Carlo Bo”, via O. Ubaldini 17, 61029 Urbino (PU), Italy
bDipartimento di Patologia Molecolare e Terapie Innovative, Università Politecnica delle Marche, via Brecce Bianche, 60131 Ancona, Italy
cIstituto di Clinica Medica I, Università di Palermo, P.zza delle Cliniche 2, 90127 Palermo, Italy
dIstituto di Ecologia e Biologia Ambientale, Università di Urbino “Carlo Bo”, Via I. Maggetti 22, 61029 Urbino (PU), Italy
CD38 has been widely characterised both as an ectoenzyme and as a receptor. In the present paper, we investigated the role of CD38 as possible modulator of apoptosis. CD38-positive (CD38+) and negative (CD38−) fractions, obtained by sorting CD38+ cells from lymphoma T (Jurkat) and lymphoma B (Raji) and by transfecting lymphoma LG14 and myeloid leukemia K562 cell lines, were used. Cellular subpopulations were exposed to different triggers (H
Key words: CD38, Apoptosis, Lymphoma T cells, Lymphoma B cells, Myeloid leukemia cells.
*Corresponding author. Tel.: +39 722 303438; fax: +39 722 303436.
Received 15 February 2006/11 April 2006; accepted 10 May 2006doi:10.1016/j.cellbi.2006.05.004