|Cancer||Cell death||Cell cycle||Cytoskeleton||Exo/endocytosis||Differentiation||Division||Organelles||Signalling||Stem cells||Trafficking|
Cell Biology International (2007) 31, 459472 (Printed in Great Britain)
Experimental alcoholism and pathogenesis of prostatic diseases in UChB rats
Eduardo Marcelo Cåndidoa, César Alexandre Fabrega Carvalhoa, Francisco Eduardo Martinezb and Valéria Helena Alves Cagnona*
aDepartment of Anatomy, Institute of Biology, State University of Campinas—UNICAMP, P.O. Box 6109, Campinas, 13083970 São Paulo, Brazil
bDepartment of Anatomy, Institute of Biosciences, State University of São Paulo—UNESP, Botucatu, São Paulo, Brazil
Previous studies have shown that long-term alcohol treatment has negative effects on prostatic stromal–epithelial interaction. Thus, the aim of the present study was to analyze the histochemical, immunohistochemical and ultrastructural alterations that occur in the prostatic stroma and epithelium of rats submitted to chronic alcohol ingestion and alcohol abstinence, as well as to establish the relationship between these changes and prostatic diseases. Thirty male rats (10 Wistar and 20 UChB rats) were divided into three experimental groups: the control group received tap water, the alcoholic group received ethanol diluted to 10° G.L. for 150
Key words: Alcoholism, UChB rat, Prostate, Stromal–epithelial interaction, Morphology.
*Corresponding author. Tel.: +55 19 3788 6102; fax: +55 19 3289 3124.
Received 28 July 2006/24 September 2006; accepted 5 November 2006doi:10.1016/j.cellbi.2006.11.009