|Cancer||Cell death||Cell cycle||Cytoskeleton||Exo/endocytosis||Differentiation||Division||Organelles||Signalling||Stem cells||Trafficking|
Cell Biology International (2007) 31, 546553 (Printed in Great Britain)
A reducing redox environment promotes C2C12 myogenesis: Implications for regeneration in aged muscle
Jason M. Hansena, Markus Klassa, Craig Harrisb and Marie Csetea*
aDepartment of Anesthesiology, School of Medicine, Emory University, 1462 Clifton Road NE, Suite 420, Atlanta, GA 30322, USA
bToxicology Program, Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
Intracellular redox potential of skeletal muscle becomes progressively more oxidized with aging, negatively impacting regenerative ability. We examined the effects of oxidizing redox potential on terminal differentiation of cultured C2C12 myoblasts. Redox potentials were manipulated by changing the culture O
Key words: C2C12 myoblast, Muscle aging, Myoblast, Myogenin, Redox potential.
*Corresponding author. Tel.: +1 404 712 2588; fax: +1 404 712 2585.
Received 7 December 2005/13 November 2006; accepted 29 November 2006doi:10.1016/j.cellbi.2006.11.027