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Cell Biology International (2007) 31, 724732 (Printed in Great Britain)
Effects of taxol treatment on the microtubular system and mitochondria of Tetrahymena
P. Kovácsa, G. Csabaa*, Éva Pállingerb and Renate Czakerc
aDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad tér 4, POB 370, H-1445 Budapest, Hungary
bMolecular Immunological Research Group, Hungarian Academy of Sciences, Budapest, Hungary
cCenter of Anatomy and Cell Biology, Medical University, Vienna, Austria
Complex investigation was done using immunocytochemical confocal microscopy, electron microscopy and flow cytometry on the effect of taxol to the microtubular arrangement and dynamics. The most interesting phenomenon was the rapid disappearance of transversal microtubule bands, while longitudinal microtubule bands remained and were submitted to the known effects of taxol. There was a broad variation in mitochondrial effect, some of them remained normal, while others swollen, desintegrated and their tubules disoriented. Treatment with 50
Key words: Microtubules, Taxol, Tetrahymena, Transversal microtubule band.
*Corresponding author. Tel.: +36 1 210 2950; fax: +36 1 303 6968.
Received 30 October 2006/12 December 2006; accepted 10 January 2007doi:10.1016/j.cellbi.2007.01.004