|Cancer||Cell death||Cell cycle||Cytoskeleton||Exo/endocytosis||Differentiation||Division||Organelles||Signalling||Stem cells||Trafficking|
Cell Biology International (2009) 33, 207216 (Printed in Great Britain)
Pyrimidone derivative inhibits simian immunodeficiency virus-induced apoptosis of CEM x174 cells
Libo Gaoa1, Shigan Fub1, Hui Lia, Xiaowei Wangc, Junyi Liuc, Han Liua, Liyuan Guoa, Xinhua Liua, Mengsen Lia, Michael A. McNuttd and Gang Lia*
aDepartment of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100083, PR China
bDepartment of Pathophysiology, Hainan Medical Collage, Haikou 570102, PR China
cDepartment of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083, PR China
dDepartment of Pathology, Peking University Health Science Center, Beijing 100083, PR China
The biochemical effects of 2-(ethoxymethylthio)-9-phenyl-cyclohepta[d]pyrimidone (EPCP), a novel non-nucleoside reverse transcriptase inhibitor, have been investigated. Treatment with EPCP (EC
Key words: Apoptosis, Cell cycle, Pyrimidone, Reverse transcriptase, Simian immunodeficiency virus.
1Libo Gao and Shigan Fu contributed equally to this study.
*Corresponding author. Tel./fax: +86 10 82802891.
Received 14 April 2008/17 July 2008; accepted 12 November 2008doi:10.1016/j.cellbi.2008.11.005