|Cancer||Cell death||Cell cycle||Cytoskeleton||Exo/endocytosis||Differentiation||Division||Organelles||Signalling||Stem cells||Trafficking|
Cell Biology International (2009) 33, 318324 (Printed in Great Britain)
RBP-Jκ binds to and represses transcription of the p53 tumor suppressor gene
Kristy Boggs1, Brystol Henderson and David Reisman*
Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA
The tightly regulated expression of p53 contributes to genomic stability and transcription of the p53 gene is induced prior to cells entering S-phase, possibly as a mechanism to insure a rapid p53 response in the event of DNA damage. We have previously described the cloning of an additional 1000
Key words: Gene expression, Cell cycle, DNA binding.
1Present address: Department of Hematology–Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
*Corresponding author. Tel.: +1 803 777 8108; fax: +1 803 777 4002.
Received 25 July 2008/26 September 2008; accepted 5 December 2008doi:10.1016/j.cellbi.2008.12.005