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Cell Biology International (2009) 33, 453–465 (Printed in Great Britain)

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TNF superfamily: Costimulation and clinical applications

Dass S. Vinay^a and Byoung S. Kwon^bc*

^aSection of Clinical Immunology, Allergy, and Rheumatology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA, USA
^bDepartment of Ophthalmology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, LA, USA
^cCell and Immunobiology and R&D Center for Cancer Therapeutics, National Cancer Center, Ilsan, Gyeonggi-Do, Republic of Korea

Abstract

The molecules concerned with costimulation belong either to the immunoglobulin (Ig) or tumor necrosis factor (TNF) superfamily. The tumor necrosis superfamily comprises molecules capable of providing both costimulation and cell death. In this review we briefly summarize certain TNF superfamily receptor–ligand pairs that are endowed with costimulatory properties and their importance in health and disease.

Key words: TNF superfamily, Costimulation, T cells, Antigen presenting cells, Immune regulation.

^*Corresponding author. Cell and Immunobiology and R&D Center for Cancer Therapeutics, National Cancer Center, 111 Jungbalsan-Ro, Ilsan, Goyang, Gyeonggi-Do 410-769, Republic of Korea. Tel.: +82 31 920 2531; fax: +82 31 920 2542.

Received 2 December 2008; accepted 4 February 2009