|Cancer||Cell death||Cell cycle||Cytoskeleton||Exo/endocytosis||Differentiation||Division||Organelles||Signalling||Stem cells||Trafficking|
Cell Biology International (2009) 33, 10651072 (Printed in Great Britain)
Melanomas display increased cytoprotection to hypericin-mediated cytotoxicity through the induction of autophagy
Lester M. Davids*, Britta Kleemann, Susan Cooper and Susan H. Kidson
Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory, 7925 Cape Town, South Africa
Photodynamic therapy (PDT) as a regime for melanoma is of limited success due to factors such as the efficacy of the photosensitizer used, penetration depth and the presence of pigment. We characterised a pigmented and an unpigmented melanoma cell line with respect to their phenotypes. Cell viability was assessed after exposure to hypericin, a UVA-activated photosensitizer. Exposure to 3
Key words: Hypericin, Photodynamic therapy, Melanoma, Autophagy, Apoptosis.
*Corresponding author. Tel.: +27 21 406 6787; fax: +27 21 448 7226.
Received 5 December 2008/22 May 2009; accepted 27 June 2009doi:10.1016/j.cellbi.2009.06.026