|Cancer||Cell death||Cell cycle||Cytoskeleton||Exo/endocytosis||Differentiation||Division||Organelles||Signalling||Stem cells||Trafficking|
Cell Biology International (2009) 33, 11351143 (Printed in Great Britain)
Human chorionic gonadotropin (hCG) prevents the transformed phenotypes induced by 17 β-estradiol in human breast epithelial cells
Hilal Kocdor, Mehmet A. Kocdor, Jose Russo, Kara E. Snider, Johana E. Vanegas, Irma H. Russo and Sandra V. Fernandez*
Fox Chase Cancer Center, Breast Cancer Research Laboratory, 333 Cottman Ave., Philadelphia, 19111 PA, USA
Human chorionic gonadotropin (hCG), a hormone produced during pregnancy, can elicit life-long refractoriness to carcinogenesis by differentiation of the breast epithelium. Human breast epithelial cells MCF-10F form tubules in collagen, mimicking the normal ductules. We have shown that 17 β-estradiol (E2) alter the ductulogenic pattern of these cells. The effect of the recombinant hCG (rhCG) in vitro was evaluated on the transformation of MCF-10F induced by E2. MCF-10F cells were treated with 70
Key words: Mammary epithelium, hCG, Estrogen, Neoplastic transformation, Branching morphogenesis.
*Corresponding author. Tel.: +1 215 728 4778; fax: +1 215 728 2180.
Received 7 January 2009/28 May 2009; accepted 25 July 2009doi:10.1016/j.cellbi.2009.07.002