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Cancer Cell death Cell cycle Cytoskeleton Exo/endocytosis Differentiation Division Organelles Signalling Stem cells Trafficking
Cell Biology International (2010) 34, 339–342 (Printed in Great Britain)
Review article
Correlation between the interaction of the vinculin tail domain with lipid membranes, its phosphorylation and cell mechanical behaviour
Wolfgang H Goldmann1
Center for Medical Physics and Technology, Biophysics Group, FriedrichAlexanderUniversity of ErlangenNuremberg, Henkestrasse 91, 91052 Erlangen, Germany

Cell adhesion and cell–cell contacts are a pre-requisite for proper metabolism, protein synthesis and cell survival. Integrins are the transmembrane receptors that link the extracellular matrix via the FAC (focal adhesion complex) with the cytoskeleton. Vinculin is a pivotal FAC protein that has not only been implicated in regulating FAC formation and transmitting mechanical forces, but also in associating with membranous lipids in biological systems.

Key words: cell mechanics, focal adhesions, lipid–membrane interaction, vinculin tail

Abbreviations: FAC, focal adhesion complex, PIP2, phosphatidylinositol 4,5-bisphosphate


Received 2 February 2010; accepted 4 February 2010

Published online 8 March 2010, doi:10.1042/CBI20100085

© The Author(s) Journal compilation © 2010 Portland Press Limited

ISSN Print: 1065-6995
ISSN Electronic: 1095-8355
Published by Portland Press Limited on behalf of the International Federation for Cell Biology (IFCB)