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Cancer Cell death Cell cycle Cytoskeleton Exo/endocytosis Differentiation Division Organelles Signalling Stem cells Trafficking
Cell Biology International (2010) 34, 907–909 (Printed in Great Britain)
Commentary
Addressing the design of in vitro models for the investigation of microcystins: the essential role of transporter-mediated uptake
Noel R Monks*1 and Jeffrey A Moscow†
*Van Andel Research Institute, Grand Rapids, MI 49503, U.S.A., and †Department of Pediatrics, University of Kentucky, Lexington, KY 40536, U.S.A.


This article discusses the need for transporter-mediated uptake for investigations addressing the mechanism of action of microcystins [with reference to the previous article in Cell Biology International by de Souza Votto (2007) 31:1359–1366].


Key words: in vitro models, microcystin, organic anion transporting polypeptide (ONTP), transporter-mediated uptake

Abbreviations: MC-LR, microcystin-LR, MDR, multidrug resistance, MOA, mechanism of action, NSCLC, non-small cell lung cancer, OATP, organic anion transporter

1To whom correspondence should be addressed (email noel.monks@vai.org).


Received 3 April 2010/6 May 2010; accepted 24 May 2010

Published as Cell Biology International Immediate Publication 24 May 2010, doi:10.1042/CBI20100244


© The Author(s) Journal compilation © 2010 Portland Press Limited


ISSN Print: 1065-6995
ISSN Electronic: 1095-8355
Published by Portland Press Limited on behalf of the International Federation for Cell Biology (IFCB)