|Cancer||Cell death||Cell cycle||Cytoskeleton||Exo/endocytosis||Differentiation||Division||Organelles||Signalling||Stem cells||Trafficking|
Addressing the design of in vitro models for the investigation of microcystins: the essential role of transporter-mediated uptake
Noel R Monks*1 and Jeffrey A Moscow†
*Van Andel Research Institute, Grand Rapids, MI 49503, U.S.A., and †Department of Pediatrics, University of Kentucky, Lexington, KY 40536, U.S.A.
This article discusses the need for transporter-mediated uptake for investigations addressing the mechanism of action of microcystins [with reference to the previous article in Cell Biology International by de Souza Votto (2007) 31:1359–1366].
Key words: in vitro models, microcystin, organic anion transporting polypeptide (ONTP), transporter-mediated uptake
Abbreviations: MC-LR, microcystin-LR, MDR, multidrug resistance, MOA, mechanism of action, NSCLC, non-small cell lung cancer, OATP, organic anion transporter
1To whom correspondence should be addressed (email email@example.com).
Received 3 April 2010/6 May 2010; accepted 24 May 2010
Published as Cell Biology International Immediate Publication 24 May 2010, doi:10.1042/CBI20100244
© The Author(s) Journal compilation © 2010 Portland Press Limited