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Cancer Cell death Cell cycle Cytoskeleton Exo/endocytosis Differentiation Division Organelles Signalling Stem cells Trafficking
Cell Biology International (2010) 34, 1091–1094 (Printed in Great Britain)
Review article
Discrepant effects of mammalian factors on molluscan cell motility, chemotaxis and phagocytosis: divergent evolution or finely tuned contingency?
Davide Malagoli and Enzo Ottaviani1
Department of Biology, University of Modena and Reggio Emilia, Modena, Italy


Cell motility, cell migration and phagocytosis are distinct, though frequently sequential, processes. They are fundamental for the maintenance of homoeostasis in single cells as well as in pluricellular organisms. Like vertebrates, invertebrate immune functions are strictly dependent on cell motility, chemotaxis and phagocytosis. Several comparative immunobiology experiments have tested the effects of mammalian factors on cell migration and phagocytic activity in invertebrate immune-competent cells. The discrepancies that were found suggest various hypotheses, e.g. species-specific reactions to heterologous factors. Here, we reconsider data concerning the effects of POMC (proopiomelanocortin)-derived peptides, cytokines and growth factors on molluscan immunocytes in the light of recent findings that also encompass the effects of experimental conditions.


Key words: cell migration, innate immunity, invertebrate, phagocytosis

Abbreviations: ACTH, adrenocorticotropic hormone, CRH, corticotrophin-releasing hormone, IL, interleukin, PDGF-AB, platelet-derived growth factor, POMC, proopiomelanocortin, TGF-β1, transforming growth factor-β, TNF-α, tumour necrosis factor-α, YTX, yessotoxin

1To whom correspondence should be addressed (email enzo.ottaviani@unimore.it).

Part of a series marking the 70th birthday of the Cell Biology International Editor-in-Chief Denys Wheatley


Received 12 July 2010; accepted 26 July 2010

Published online 24 September 2010, doi:10.1042/CBI20100514


© The Author(s) Journal compilation © 2010 Portland Press Limited


ISSN Print: 1065-6995
ISSN Electronic: 1095-8355
Published by Portland Press Limited on behalf of the International Federation for Cell Biology (IFCB)