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Cell Biology International (2010) 34, S66 (Printed in Great Britain)
Compared with vitamin A plus iron and multiple micronutrient supplementations, solely vitamin A fortified seasoning powder affect iron metabolic index without changing body total iron contents in children
Ke Chen1, TingYu Li2, Li Chen2, Ping Qu2 and YouXue Liu2
1Department of Child Health Care, Chengdu Maternal and Children Health Care Hospital, 32 Shiye Street, Chengdu, 610031, Sichuan Province, PR China, and 2Department of Child Health, Children's Hospital, Chongqing Medical University, 136 Second Zhongshan Road, Chongqing 400014, PR China
The present study to evaluate the effect of vitamin A on iron metabolic homeostasis and total body iron content. A total of 226 2-7 years old preschool children were recruited and randomly assigned into three diet groups for 6 months. Group I was fortified with vitamin A; Group II and III were fortified with vitamin A plus iron and vitamin A plus iron, thiamine, riboflavin, folic acid, niacinamide, zinc and calcium. The concentration of serum vitamin A, serum ferritin (SF), serum transferring receptor (sTfR), C-reactive protein (CRP) and hemoglobin (HB) were measured and TFR-F index and total body iron content (TBIC) were computed before and after intervention. The levels of HB significantly increased after intervention in all groups (p< 0.05) but no marked difference was observed between groups (p>0.05). Levels of SF and sTfR significantly decreased after intervention in all groups (p< 0.05) especially in group II and group III for SF (p< 0.05) and group I for sTfR (p< 0.05). No marked change of TFR-F index and TBIC was observed in group I (p>0.05), while TFR-F index decreased and TBIC increased in group II and group III (p< 0.05) after intervention. Compared with vitamin A intervention, the other two supplementations were significant protective factors for deficient iron storage defined by TFR-F index [(relative risk, RR) (95% CI): 0.410(0.218, 0.992)]. Vitamin A intervention has significant effect on iron storage and mobilization, but has no significant effect on TFR-F index and TBIC which prompted the possibility of seldom effect of vitamin A on iron absorption in small intestine.
Published online 1 August 2010, doi:10.1042/CBI034S066d
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