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Cancer Cell death Cell cycle Cytoskeleton Exo/endocytosis Differentiation Division Organelles Signalling Stem cells Trafficking
Cell Biology International (2011) 35, 453–455 (Printed in Great Britain)
Protein balance: a fundamental question of cell biology needing reappraisal
Denys N Wheatley1

Although protein synthesis and protein degradation are two independent processes that are firmly regulated, how they maintain a balance of protein in the non-growing cell remains to be established. In work in the 1980s, the author suggested a self-regulating mechanism. However, experimental work on this interesting and fundamental problem is needed for a better understanding of ‘protein balance’ in cells.

Key words: protein balance, protein degradation, protein protein synthesis, self-reguating mechanism.


Received 27 January 2011; accepted 1 February 2011

Published online 30 March 2011, doi:10.1042/CBI20110067

© The Author(s) Journal compilation © 2011 Portland Press Limited

ISSN Print: 1065-6995
ISSN Electronic: 1095-8355
Published by Portland Press Limited on behalf of the International Federation for Cell Biology (IFCB)