|Cancer||Cell death||Cell cycle||Cytoskeleton||Exo/endocytosis||Differentiation||Division||Organelles||Signalling||Stem cells||Trafficking|
Chromosome ‘by-Aurora-ientation’ during mitosis
Sally P Wheatley1
School of Biomedical Sciences, University of Nottingham, Queens Medical School, Nottingham NG7 2UH, U.K.
New evidence from three separate laboratories, published recently in Science, has shown that centromere positioning of the CPC (chromosomal passenger complex) during early mitosis is achieved through direct interaction between the CPP (chromosomal passenger protein) survivin and histone H3. In essence, an acidic pocket in the BIR (baculovirus inhibitor of apoptosis repeat) domain of survivin binds to the NH2 tail of histone H3 specifically when it is phosphorylated at threonine 3, a mark that is placed by the mitotic kinase, haspin. These data are significant, as they describe a fundamental mechanism, conserved throughout eukaryotes, which is essential for chromosome biorientation and the maintenance of genome stability during mitosis.
Key words: Aurora-B, centromere, haspin kinase, histone H3, survivin
Abbreviations: BIR, baculovirus inhibitor of apoptosis repeat, cdk1, cyclin-dependent kinase 1, CPC, chromosomal passenger complex, CPP, chromosomal passenger protein, IAP, inhibitor of apoptosis protein, INCENP, inner centromeric protein, MCAK, mitotic chromosome-associated kinesin, sgo2, shugoshin 2, T3, threonine 3
Received 27 December 2010/8 March 2011; accepted 15 March 2011
Published as Cell Biology International Immediate Publication 15 March 2011, doi:10.1042/CBI20100911
© The Author(s) Journal compilation © 2011 Portland Press Limited