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Cell Biology International (2011) 35, 1079–1083 (Printed in Great Britain)

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Review article

A challenging epigenetic message: telomerase activity is associated with complex changes in lifestyle

András Falus*, István Marton†¹, Erika Borbényi†‡, Ádám Tahy†, Pál Karádi†, János Aradi§, Adrienne Stauder‖ and Mária Kopp‖

*Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary, †Quintess Health Centre, Budapest, Hungary, ‡Radiology and Oncotherapy Clinic, Oncology Care Institute, Semmelweis University, Budapest, Hungary, §Institute of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, and ‖Department of Behavioural Sciences, Semmelweis University, Budapest, Hungary

As an outcome of The 2009 Nobel Prize in Physiology or Medicine, a connection has been highlighted between the length of telomeres and epigenetic effects, such as intensive changes in lifestyle and nutrition as well as behavioural and psychological factors. In this review, the various elements of molecular, cell biological, nutritional and lifestyle changes are introduced and discussed.

Key words: cell proliferation, complex therapy, epigenetics, food, immune response, relaxation, sport, telomere, telomerase

Abbreviations: AD, Alzheimer's disease, Cdk, cyclin-dependent kinase, CVD, cardiovascular disease, LDL, low-density lipoprotein, PBMC, peripheral blood mononuclear cell, PSA, Pisum sativum agglutinin, TERT, telomerase reverse transcriptase

¹To whom correspondence should be addressed (email martondr@chello.hu).

Received 27 January 2011/15 May 2011; accepted 31 May 2011

Published online 27 September 2011, doi:10.1042/CBI20110046

© The Author(s) Journal compilation © 2011 Portland Press Limited